Thaddeus Young added 16 points, while James Anderson and Michael Carter-Williams had 11 each for the Sixers, who snapped a two-game losing streak and improved to 4-2. Spencer Hawes scored 10 points.
The buzz leading into the game was the return of Bynum, who signed a two-year, $24 million contract with the Cavaliers in July.
Bynum had been acquired by the Sixers in a four-team, 12-player trade in the summer of 2012. But the two-time All-Star center never played for the Sixers because of bilateral bone bruises in both knees. Bynum had season-ending arthroscopic surgery in March and wound up signing the incentive-laden deal with the Cavaliers as a free agent.
He played 18 minutes off the bench and finished with four points and five rebounds as the fans cascaded boos toward him every time he touched the ball.
Dion Waiters led the Cavaliers with 18 points while Jarrett Jack and C.J. Miles added 13 each. Tristan Thompson had 13 points and 16 rebounds and Kyrie Irving contributed 10 points on 4-for-17 shooting for Cleveland, which fell to 2-4 with all four losses coming on the road.
The Sixers executed their offense efficiently in the second half and built a 19-point lead early in the fourth quarter.
Cleveland never got within single digits the rest of the way.
The Cavaliers led by as many as 14 points in the first half, but the Sixers finished the half strong and took a 44-42 advantage into the locker room.
NOTES: Cavaliers F Anthony Bennett left the game with 8:37 remaining in the second quarter and didn't return because of a sprained right shoulder. Bennett, the No. 1 overall pick in June's draft, was scoreless in six minutes and remains 1 for 20 from the field through six games. . Sixers C Daniel Orton missed the game because of right knee soreness. . The Sixers wore red, white and blue headbands in honor of Veterans Day, which is Monday.