Damian Lillard scored 16 and Dorell Wright had 15 on 5-for-5 shooting from beyond the arc. Wesley Matthews added 14 points for the Northwest Division leaders, who won their third in a row and improved to 20-4.
They became the second NBA team to reach 20 wins, joining the Indiana Pacers (20-3).
Mo Williams also had 14 points, Robin Lopez 12 and Thomas Robinson 10 for Portland, which put eight players in double figures and moved to 10-2 on the road.
Tony Wroten led the reeling Sixers with 18 points and Hollis Thompson had 17. Spencer Hawes added 16, Thaddeus Young had 15 and James Anderson 14.
Playing once again without rookie point guard Michael Carter-Williams, the Sixers have dropped six straight and 10 of the last 11 games. Carter-Williams sat out for the sixth consecutive game because of a skin infection on his right knee.
The Sixers are 1-9 without Carter-Williams, the Eastern Conference Rookie of the Month for October and November.
Portland broke open a close game with some stellar shooting, especially from beyond the arc.
The Trail Blazers hit 11 of their first 20 tries from 3-point range and were 18 for 32 by the end of the third quarter for a 111-79 lead. Wright hit No. 18 to break the club record as the third-quarter buzzer sounded.
It was the latest record-setting performance for the streaking Blazers. In their previous game two nights ago, a 111-104 victory over Houston, Aldridge posted the first 30-point, 25-rebound game in franchise history.
This time, the Trail Blazers didn't need nearly as much from Aldridge with such a balanced effort up and down the lineup.
The Sixers never posed a serious threat in the fourth.
The Blazers led by as many as seven points in the first half and wound up with a 71-64 advantage heading into the locker room.
NOTES: Wroten was whistled for a technical foul with 8:36 remaining in the third quarter. ... The 71 points allowed in the first marked the most given up by the Sixers in any half this season. ... Aldridge had a double-double for the fifth time in the last six games. ... Sixers C Daniel Orton and Trail Blazers C Meyers Leonard got tangled up on the floor and both were ejected with 7:19 left. ... Former Philadelphia Eagles running back Brian Westbrook attended the game.
