Police say two males, a 19-year-old and a 16-year-old, were both shot after being chased by another vehicle in the city's Logan section.
The gunman opened fire after the vehicle the teens were riding in crashed into an SUV at 15th and Courtland streets.
Both teen victims were rushed to an area hospital where they are expected to survive.
Police say the SUV was occupied by four people, including two girls, a 1-year-old and 8-year-old. No one inside the car was injured.
Around the same time as the Logan shooting, police say two males, a 15-year-old and a 13-year-old, were both shot in an unrelated incident on the 4900 block of Olive Street in West Philadelphia.
Both teens were transported to an area hospital where they are currently listed in stable condition.
No arrests have been made in connection with these shootings.
Anyone with information is asked to call police at 215-686-TIPS.