The incident happened Friday shortly after 5:30 p.m. in the area of 54th and Vine streets.
Police say a man fired gunshots at a 28-year-old man after he began banging on his car.
He was shot twice in the rear of his head, once in the neck, and once in the back.
He was transported to Penn Presbyterian Medical Center by police and is currently listed in extremely critical condition.
Officials say the shooting appears to be an act of road rage.
A weapon was recovered, and a suspect is currently in police custody.