The network says the 45-year-old actress will attend the June 6 ceremony to accept the MTV Generation Award, its highest honor.
The Oscar winner, who has kept a low profile since her public split from husband Jesse James, is the first woman to receive the award. Past recipients include Tom Cruise, Ben Stiller, Adam Sandler, Mike Myers and Jim Carrey.
MTV General Manager Stephen Friedman says Bullock is "adored by our audience as both an actress and a role model."
Hosted by Aziz Ansari, the MTV Movie Awards will be broadcast live from the Gibson Amphitheatre. Presenters include Sandler, Cruise, Robert Pattinson, Taylor Lautner, Chris Rock, Steve Carell and Cameron Diaz.