Aubrianna Adams-Coggins, 16, was last seen around 2:00 p.m. Monday in the Chestnut Crossing community of Newark with her four-month-old son, Daniel Stukes.
Police say Abrianna fled her home after a previous dispute with her mother.
She is described as a black female with brown hair, brown eyes, weighing 140 pounds and stands 5'5" tall.
Aubriana was last seen wearing a brown shirt, fuchsia capri pants and carrying a black diaper bag.
Anyone with information regarding her whereabouts is asked to call the New Castle County Police Department at (302) 573-2800.