It happened around 3:00 Friday morning at the intersection of Kaighns and Mt. Ephraim avenues.
Authorities say the vehicle was struck multiple times. The driver then lost control and stopped on the sidewalk.
The victims - both in their 20s - were struck by the gunfire.
One of the victims was struck in the stomach and is listed in critical but stable condition.
The second victim was hit in the leg and is in stable condition.
So far police have no motive in the shooting.