The incident happened just before 9:30 p.m. at Brunswick Avenue and Middle Rose Street.
According to police, Lewis was in a car with some other people when an argument broke out between him and the suspect who was alongside him in another car.
Both of the men got out of their vehicles and shots rang out, police say.
The victim was rushed to the hospital, where he was pronounced dead early Saturday.
Police are searching for the suspect who fled the scene.
Lewis is the 31st victim killed in Trenton this year. His murder ties the record set in 2005 for the most homicides in a year.