It happened around 6:50 Friday evening in the eastbound lanes of Girard Avenue near 7th Street.
Police say 54-year-old Sheila Morgan-Hailey was running across Girard Avenue in an attempt to catch a trolley when she was hit by a 1996 Black Volkswagen.
The victim was rushed to Hahnemann Hospital in critical condition and later succumbed to her injuries.
Authorities say the driver did stop at the scene.
An investigation is ongoing.