It happened around 2:00 p.m. on the highway near Washington Avenue.
When police arrived they found that a car hit a concrete barrier.
Police say the driver switched lanes and ran into a tractor trailer tire.
The children in the car were not in child seats and may have contributed to their injuries.
Officers took two children to Children's Hospital, one with a laceration to the head.
The two adults in the vehicle were taken to the hospital with minor injuries.
