Representatives for the House of Blues say Santana will have a run of shows in May and June, then return in September with the residency running through 2013. Tickets go on sale March 3.
Santana says he's happy to call the venue home, and plans to honor the diversity and culture that the House of Blues promotes as a company.
Part of each ticket sale will go to Santana's foundation, which supports children's art, education and health.
