It happened in the 5800 block of Jackson Street around 6:30 p.m.
Police say the suspects apparently used a ladder to break into a second floor side window.
The homeowners owned the bar Mama's Lounge in North Philadelphia.
They had just sold it, which is why they say they had so much cash at home.
One of the victims says it's the first time they had money there, so she feels she was targeted by someone who knew.
Along with the cash and jewelry, precious items of the couple's children were also taken.
The suspects also stole a DVR which recorded surveillance video evidence of their crimes from the home's three cameras.
At this time, there are no details on the suspects.