The accident happened around 11:30 p.m. on East Welsh Road and Dillion Road.
According to investigators, three motorcycles, a SUV, and a car were involved in the crash.
One motorcyclist was killed in the collision. The other two motorcyclists were hospitalized following the crash. There is no word on their condition at this time.
There were no reported injuries to the operators of the car or SUV.
Police are investigating what may have led to the deadly accident.