Bradley Beal had 17 points, Trevor Ariza scored 15 as seven Wizards reached double digits to help Washington earn its first win after starting 0-3.
Evan Turner led Philadelphia with 24 points and Spencer Hawes had 13. Rookie Michael Carter-Williams finished with 19 points, seven assists and five rebounds.
After a surprising 3-0 start, the Sixers have lost two straight and are starting to play like the team that oddsmakers predicted would win less than 17 games this season.
The Sixers sandwiched wins over Miami and Chicago with a comeback win at Washington last week. They overcame a 12-point, third-quarter deficit to beat the Wizards 109-102 and spoil their home opener on Friday.
The Wizards led this one from the opening basket and never let up. They had a 15-point lead midway through the first quarter after Beal hit his third 3-pointer in three tries, and took a 60-51 lead into halftime.
The Sixers got close in the third following an 11-3 run. Turner started it with a pull-up jumper and he hit another jumper and 3-pointer during the stretch. Hawes' layup cut it to 71-67, but Wall answered with a 3, and Gortat and Nene scored on tip-ins to extend the lead to 78-67.
Beal's jumper to start the fourth put the Wizards up by 15 and they led by double digits the rest of the way.
The fast start had Sixers fans feeling a bit perplexed. Many are hoping for the team to lose so they could end up with the No. 1 overall pick so they could draft Kansas prospect Andrew Wiggins. But first-year coach Brett Brown and his team generated some early excitement so that created a dilemma for some fans who wanted the team to go winless for Wiggins.
NOTES: The Wizards shot 18 for 33 from 3-point range. The 18 3s tied a floor record. Seattle had 18 at the Wells Fargo Center on Nov. 16, 2004. ... Philadelphia's Daniel Orton left the game because of right knee soreness. He had five points in six minutes. ... The Sixers outshot the Wizards 47 percent to 43.9, but Washington's 3s made the difference. Philadelphia was 6 for 18 from beyond the arc.