The accident happened Friday just before 6 p.m. outside Abessinio Stadium on Saint Rocco Way.
Police say a vehicle hit pedestrians. One of the victims was reportedly flown to the hospital.
Salesianum High School was hosting Middletown High School in a homecoming high school football game.
So far, there is no word yet on the conditions of those injured.
Salesianum High School issued a statement on their Facebook page that reads:
"Tonight's game has been postponed due to a vehicle accident with injuries in the parking lot of Abessinio Stadium prior to kickoff. No Middletown or Salesianum students were injured.
Natural Resources Police are conducting an investigation. Information regarding the game will be shared when it is available.
In the meantime, please join the Salesianum community in praying for those affected as we ask God to shed his healing grace on the injured."
Investigators say the incident is being investigated as an accident and nothing more.