The four-vehicle crash occurred shortly before 4 a.m. on I-76 west at Spring Garden Street in Philadelphia.
The crash involved two jack-knifed tractor-trailers, with one spilling fuel.
According to officials, at least 20 gallons of fuel leaked onto the highway.
Around 6:50 a.m., one lane of traffic was allowed to get by the scene.
Just after 9 a.m., the scene was cleared.
A dump truck collided with a milk truck around midnight on northbound I-95 in Chester, Delaware County.
The collision and resulting spill shut down I-95 NB between Market Street and Route 322.
I-95 reopened around 6 a.m.
There is no word on any injuries in either crash.