The pursuit started around 8:30 p.m. near Tyson and Torresdale avenues in the city's Tacony neighborhood.
Philadelphia police said it was a minor traffic infraction that led to a low-speed pursuit. The male driver was traveling the wrong way down Torresdale Avenue and drove off during an initial traffic stop.
The suspect led officers onto I-95 and eventually out of the city.
Chopper 6 was overhead as the suspect's vehicle began sparking on the highway during the daring escape.
Around 9:30 p.m. the door of the vehicle opened up near the St. Davids exit of the Blue Route. Someone then exited from the driver's seat and ran into the woods near the train overpass on I-476 between Archbishop Caroll and Villanova University's tennis complex.
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After the suspect ditched the vehicle, officers continued the pursuit on foot with flashlights and canines near the Villanova train stop.
"We could hear all the helicopters and see all the lights. We could hear the people shouting, trying to hunt down on the train tracks," said Brette Husar of Villanova.
Radnor Township police said they assisted Philadelphia and Pennsylvania State Police with a foot pursuit.
"There's a theory that he used the railway to get out of the area," said Radnor Township Police Superintendent Christopher Flanagan. "It is a possibility, but we never identified him 100%, so we didn't know which way he went to get out of the area."
Although the suspect remains at large, Radnor Township police said there is no threat to public safety.
Anyone with information is asked to call police.