It happened around midnight Sunday on the 1800 block of East Tusculum Street.
According to police, a 38-year-old man died at the hospital after being shot multiple times.
The shooting also seriously injured a 34-year-old woman.
At least 25 shell casings were found at the scene.
No arrests have been made at this time.
Anyone with any information is asked to call police at 215-686-TIPS.