It happened around 3:55 a.m. Friday on the northbound lanes of 42, by the exit of the Black Horse Pike (9B).
Police say the driver of a vehicle carrying three people lost control and struck a tree.
Rescue crews responded to the scene and extricated two people from the vehicle.
One person was pronounced dead at the scene.
Delays were expected around the crash site as police blocked lanes while they continued to investigate.
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